None
Conditions
Interventions
Experimental Group:Retrosternal nerve block using bupivacaine liposome combined with dexamethasone
Control Group:Bupivacaine liposome intercostal nerve block combined with intravenous dexamethasone
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years; 2. Patients scheduled for uniportal thoracoscopic-assisted lobectomy/segmentectomy under general anesthesia; 3. Agree to receive intercostal nerve block and postoperative intravenous patient-controlled analgesia.
Exclusion criteria
Exclusion criteria: 1. Cases of staged open-chest surgery; 2. Patients with coagulation dysfunction (INR > 1.7, APTT exceeds the normal value by 4 seconds, platelet count 442 µmol/L or requiring renal replacement therapy), liver dysfunction (Child-Pugh class C), or ASA class = IV; 4. BMI = 30 kg/m^2 or = 15 kg/m^2; 5. Chronic opioid dependence and long-term use of various types of analgesics (more than 3 months), such as those with long-term back pain; 6. Preoperatively unable to communicate due to severe dementia, language disorder, or terminal illness; 7. Recent use of antipsychotic medications; 8. Alcohol and/or drug abuse; 9. Known allergy to local anesthetics; 10. Other conditions deemed by the attending physician or researcher as unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve of the Numerical Rating Scale (NRS) for pain intensity after 36-60 hours of postoperative activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| The dosage of opioid drugs;Pain score (at rest and during activity);Adverse events related to nerve block; | — |
Countries
China
Contacts
Public ContactSong Linlin
Peking University First Hospital
Outcome results
None listed