Excessive levels of heavy metals
Conditions
Interventions
Life Intervention Group:Daily supplementation of minerals and vitamins, along with lifestyle interventions such as physical exercise, for a total treatment course of 4 weeks.
Probiotic Intervention plus Lifestyle Intervention Group:Probiotics (containing 10^9 CFU of live probiotics and prebiotics), 1 packet, twice daily (bid), combined with daily supplementation of mineral
Limosilactobacillus reuteri[Product Preservation No. and Batch No.: B80650=ATCC 23272
20241205])
Sponsors
West China Fourth Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-60 years old, occupational exposure workers. 2. Occupational exposure history: Engaged in heavy metal mining or metallurgical-related industries, with lead exposure >=3 months, mercury exposure >=6 months, arsenic exposure >=3 months, cadmium exposure >=1 year, and no withdrawal from the exposure environment within the past 3 months. 3. Occupational populations exceeding the aforementioned standards but not meeting the diagnostic criteria for occupational poisoning, in accordance with guidelines and standards such as the WHO Clinical Management Guidelines for Lead Exposure, Biological Limit Values for Occupational Exposure to Mercury (WST 265-2006), Safe Guideline Levels for Arsenic in Human Urine (WST 665-2019), and the EU Occupational Biological Limit Values (Directive (EU) 2019/983). 4. Heavy metal standards for human biological samples: Blood lead level >=50 µg/L; Urinary mercury >=20 µmol/mol creatinine (>=35 µg/g creatinine); Urinary arsenic >=32 µg/L Urinary cadmium >=2 µg/g creatinine;
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women. 2. Concomitant severe diseases: hepatic or renal insufficiency (ALT>80 U/L or Cr>133 µmol/L), malignant tumors, and autoimmune diseases. 3. Recent intervention history: Use of antibiotics, probiotics, or heavy metal chelators within 4 weeks prior to intervention. 4. Allergy history: Allergy to dairy products or probiotic components. 5. High risk of lost to follow-up: Inability to ensure follow-up compliance (e.g., frequent business trips, remote residence locations).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood and urine heavy metal load;Alpha/beta diversity index of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Symptoms and Signs ;Inflammatory markers: IL-6, CRP;Metabolic indicators: blood glucose, insulin levels; | — |
Countries
China
Contacts
Public ContactDu Yu
West China Fourth Hospital, Sichuan University
Outcome results
None listed