Breast Cancer
Conditions
Interventions
Luteal Phase group:None
Non-luteal Phase group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients voluntarily join this study and sign the informed consent form; 2. Age 18-55 years old; 3. ASA grade I-III; 4. Female patients; 5. Non-amenorrhea; 6. In the luteal phase or non-luteal phase (excluding menstruation); 7. Mild to severe depressive symptoms (11 points< MADRS< 35 points); 8. Elective unilateral radical breast cancer resection is planned.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative chemoradiotherapy or endocrine therapy and patients with secondary surgery (recurrence or reconstruction); 2. BMI >30kg/m ²; 3. Mental illness, bipolar disorder or medical history; 4. History of antidepressant treatment within 2 weeks; 5. Patients with obvious abnormal liver and kidney function before surgery; 6. Unable to cooperate with the investigator for any reason: such as hearing or visual impairment, language comprehension disorder, mental illness, etc; 7. History of drug dependence or current pregnancy or breastfeeding; 8. Plan to enter the ICU before surgery; 9. Have participated in other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of depression 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of depression at 1 day after the operation, 7 days after the operation, 4 weeks after the operation and 12 weeks after the operation;Severity of depression;The incidence of severe postoperative pain;Changes in blood BDNF content;Intraoperative electroencephalographic features;The number of additional postoperative analgesics;Postoperative hospital stay days; | — |
Countries
China
Contacts
Public ContactMei Bin
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed