Alzheimer’s Disease(AD)
Conditions
Interventions
control group:Repetitive transcranial magnetic stimulation (rTMS)+ routine activities
Intervention group: repetitive transcranial magneticstimulation, rTMS + Cognitive Stimulation Therapy,CST
Sponsors
The Affiliated Brain Hospital , Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for moderate to severe neurocognitive impairment as outlined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 2. Aged 60 or above; 3. Score of 10 to 24 on the Mini-Mental State Examination (MMSE); 4. Clinical Dementia Rating Scale (CDR) score = 2 (and = 0.5); 5. Taking anti-dementia drugs (cholinesterase inhibitors and memantine) and antipsychotic drugs (quetiapine, olanzapine, or risperidone); 6. The patient possesses a certain degree of language comprehension and communication ability; 7. Have good vision and hearing, and be able to use most of the materials used in treatment; 8. The patient and/or their family members sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Exclude major physical illnesses such as pneumonia, malnutrition, severe cardiovascular disease, etc; 2. Exclude serious behavioral symptoms, such as speaking loudly or continuously, wandering, shouting, attacking, etc; 3. Exclude dementia caused by other diseases, such as vascular dementia, frontotemporal dementia, Lewy body dementia, etc; 4. Exclude patients with pseudodementia caused by depression (Hamilton Depression Scale score = 17); 5. Exclude patients with a history of mental illness (such as schizophrenia);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive function;behavioral and psychological symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Live; | — |
Countries
China
Contacts
Public ContactBo Li
The Affiliated Brain Hospital , Guangzhou Medical University
Outcome results
None listed