Prostate cancer
Conditions
Interventions
Gold Standard:According to the clinical diagnostic criteria
Index test:Marker: Enantiomers of chiral amino acids Detection methods: Raman and electrochemical
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion Criteria for the Prostate Cancer Patient Group 1.Clinically and histopathologically confirmed prostate cancer (by needle biopsy or postoperative pathological examination). 2. No restriction on clinical stage, but the diagnosis must be supported by complete medical records and relevant examination data. 3.No chemotherapy, radiotherapy, endocrine therapy, targeted therapy, immunotherapy, or other antitumor interventions for at least 1 week prior to blood collection (or a uniform therapeutic window as specified by the study protocol). 4. No history of other malignant tumors, or prior other malignancies with complete remission for =5 years without recurrence or metastasis. 5. No severe hepatic or renal failure, and no dysfunction of vital organs including the heart, lung, or brain. 6. No severe urinary system diseases (e.g., gross hematuria, pyuria, severe proteinuria) that would markedly interfere with urine testing. Inclusion Criteria for the Healthy Volunteer Group 1. No history of prostate cancer or other malignant tumors. 2. Normal results on routine screening including digital rectal examination (DRE) and prostate-specific antigen (PSA) testing;no acute exacerbation of benign prostatic hyperplasia or acute prostatitis. 3. No severe diseases of the liver, kidney, heart, lung, endocrine system, or metabolism. 4. No autoimmune diseases or chronic infectious diseases (e.g., active hepatitis, tuberculosis). 5. No medications that may significantly affect metabolism, hormone levels, or chiral substance metabolism within the past 3 months. 6. No obvious abnormalities in routine blood test, routine urine test, liver function, renal function, or other basic examinations.
Exclusion criteria
Exclusion criteria: Exclusion Criteria (subjects will be excluded if meeting any one item) 1. Female participants. 2. Age < 18 years. 3. Individuals unable to provide informed consent or cooperate with sample collection. 4. Ineligible samples due to insufficient volume, severe hemolysis, serious contamination, excessive dilution, or improper storage. 5. History of acute infection, fever, inflammation, severe pain, trauma, or surgery within the past 1 week. 6. Heavy alcohol consumption, strenuous exercise, staying up late, overeating, or intake of special health products or Chinese herbal preparations within the past 3 days. 7. Current use of glucocorticoids, immunosuppressants, cytotoxic drugs, or other medications that may interfere with metabolism and chiral substance levels;recent history of blood transfusion, plasma exchange, dialysis, or other related treatments;alcoholism or drug abuse. 8. Severe hepatic or renal insufficiency, severe cardiovascular or cerebrovascular diseases, acute diabetic complications, or other conditions that affect substance metabolism in vivo. 9. Presence of other malignant tumors, autoimmune diseases, or hematological diseases. 10. Severe hematuria, proteinuria, urinary tract infection, renal failure, or other conditions that significantly interfere with urine test indicators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enantiomers of chiral amino acids; | — |
Countries
China
Contacts
Public ContactMing Li
The First Affiliated Hospital of Ningbo University
Outcome results
None listed