Knee-related diseases requiring total knee arthroplasty (TKA)
Conditions
Interventions
Adjuvant group:During the fascia iliaca compartment block, 40 ml of 0.25% ropivacaine mixed with 0.2 mg/kg esketamine was injected. Ten minutes before skin incision following anesthesia induction, 10
Intravenous administration group:During the fascia iliaca compartment block, 40 ml of 0.25% ropivacaine was injected. Ten minutes before skin incision following anesthesia induction, 10 ml of 0.2 mg/k
Control group:During the fascia iliaca compartment block, 40 ml of 0.25% ropivacaine was injected. Ten minutes before skin incision following anesthesia induction, 10 ml of normal saline was administe
Sponsors
Fuyang Hospital of Anhui Medical University.
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective total knee arthroplasty under laryngeal mask general anesthesia combined with fascia iliaca compartment block, with ASA classification I-III; 2. Aged 65-85 years; 3. BMI 18-30 kg/m²; 4. Normal communication ability; 5. Willing to participate and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Hepatic, renal, or pulmonary insufficiency, or cardiac function class III or IV; 2. Contraindications to nerve block, including allergy to local anesthetics, damage or infection at the puncture site, or coagulation disorders; 3. History of mental disorders or central nervous system diseases, or hearing or visual impairment that prevents cooperation with scale assessments; 4. Contraindications to esketamine, including high risk of severe elevation of blood pressure or intracranial pressure, allergy to esketamine, or mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The QoR-15 scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| The NRS pain scores at rest.;Total number of PCIA demands;The incidence of nausea and vomiting within 48 hours postoperatively was recorded.;Time to first ambulation postoperatively;The intraoperative dosages of propofol and remifentanil, operative time, and recovery time (time from cessation of drug infusion to eye opening) were recorded.;NRS pain score during activity;Number of effective PCIA demands;Duration of postoperative hospitalization;Remifentanil consumption;Operative time;Recovery time (time from cessation of drug infusion to eye opening); | — |
Countries
China
Contacts
Public ContactZhang Dan
Fuyang Hospital of Anhui Medical University
Outcome results
None listed