Primary aldosteronism
Conditions
Interventions
Prospective cohort (precise partial adrenalectomy group):[18F] Aldoview PET/CT functional imaging indicated partial adrenalectomy for unilateral solitary aldosterone-producing adenoma
Retrospective cohort (unilateral total adrenalectomy group):None
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Prospective cohort: 1. Hypertensive patients aged 18-75 years; 2. Diagnosed with primary aldosteronism; 3. Thin-layer enhanced CT of the adrenal glands indicates unilateral adrenal lesion and AVS suggests the same side as the dominant side; 4. [18F] Aldoview PET/CT indicates a single positive nodule on one side, with no limit on nodule size; 5. Patients willing to undergo surgical treatment; 6. Willing and able to follow the study protocol and follow-up, and sign the informed consent form. Retrospective cohort: 1. Hypertensive patients aged 18-75 years; 2. Diagnosed with primary aldosteronism; 3. Thin-layer enhanced CT of the adrenal glands indicates unilateral adrenal lesion and AVS suggests the same side as the dominant side; 4. [18F] Aldoview PET/CT indicates a single positive nodule on one side, with no limit on nodule size; 5. Underwent unilateral adrenalectomy; 6. Willing and able to follow the study protocol and follow-up, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Prospective cohort: 1.Patients with other common secondary hypertension, such as renal artery stenosis, renal parenchymal hypertension, pheochromocytoma, hypercortisolism, etc.; 2. Patients with malignant tumors or functional disorders of the heart, liver, kidney, and severe physical diseases who cannot tolerate surgery; 3. Patients with severe mental disorders or cognitive impairments who cannot cooperate with the study; 4. Patients who have undergone adrenal surgery before; 5. Patients with adrenal cortical insufficiency requiring hormone replacement therapy; 6. Patients who have been using glucocorticoids for a long time and cannot discontinue the use. Retrospective cohort: 1. Patients with other common secondary hypertension, such as renal artery stenosis, renal parenchymal hypertension, pheochromocytoma, hypercortisolism, etc.; 2. Patients with malignant tumors or functional disorders of the heart, liver, kidney, and severe physical diseases; 3. Patients with severe mental disorders or cognitive impairments who cannot cooperate with the study; 4. Patients who have undergone adrenal surgery before in the context of unilateral adrenal resection; 5. Patients with adrenal cortical insufficiency requiring hormone replacement therapy; 6. Patients who have been using glucocorticoids for a long time and cannot discontinue the use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical complete success;Clinical complete success; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clavien-Dindo degree;The incidence of postoperative adrenal cortical insufficiency;Biochemical partial success;Clinical partial success; | — |
Countries
China
Contacts
Public ContactLongfei Liu
Xiangya Hospital, Central South University
Outcome results
None listed