Primary aldosteronism
Conditions
Interventions
Primary Aldosteronism Group (APA Group):None
Non-functional Adenoma Group:None
Sponsors
The Army Specialized Medical Center of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Positive initial screening with aldosterone-renin ratio (ARR): plasma aldosterone/renin activity ratio > 30 or plasma aldosterone/renin concentration ratio > 3.7, respectively. 2.At least one positive confirmatory test, including the saline infusion test, captopril challenge test, oral high-sodium diet test, or fludrocortisone suppression test. Patients with spontaneous hypokalemia, renin levels below the lower limit of detection, and plasma aldosterone concentration > 20 ng/dL were exempt from confirmatory testing. 3.Unilateral lesion was indicated by adrenal computed tomography (CT) or adrenal vein sampling (AVS). 4.Age ranged from 18 to 75 years.
Exclusion criteria
Exclusion criteria: 1.Incomplete detection results of renin and aldosterone in the initial screening test; 2.Medications used during screening interfered with the detection of renin and aldosterone, resulting in inaccurate test results; 3.Complicated with severe cardiac, hepatic or renal insufficiency; 4.Pregnant or lactating women; 5.Individuals with drug abuse, alcohol addiction, or uncontrollable psychiatric disorders; 6.Patients with intellectual disability or immature mental capacity who are unable to control their own behaviors; 7.Those who refuse to participate in the present study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid metabolism indicators;Serum and urinary aldosterone;Pathological classification;Results of computed tomography (CT) examination;Results of adrenal vein sampling;Electrolytes; | — |
Countries
China
Contacts
Public ContactLu Zongshi
The Army Specialized Medical Center of the People's Liberation Army of China
Outcome results
None listed