Primary Membranous Nephropath
Conditions
Interventions
Healthy control group:None
PMN patient group:None
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: PMN Patient Group: 1. Aged 18-75 years, any gender; 2. Diagnosed with primary membranous nephropathy by renal biopsy pathology (according to the 2012 KDIGO diagnostic criteria); 3. Clear results for serum anti-PLA2R antibody and/or anti-THSD7A antibody tests; 4. No prior treatment with immunosuppressive agents (glucocorticoids, cyclophosphamide, tacrolimus, cyclosporine, etc.); 5. Signed informed consent. Healthy Control Group: 1. Aged 18-75 years, any gender; 2. No history of kidney disease; 3. Normal urinalysis and normal kidney function (eGFR >=90 ml/min/1.73m^2); 4. No history of autoimmune diseases; 5. No history of chronic diseases (diabetes, hypertension, liver disease, etc.); 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary membranous nephropathy (such as systemic lupus erythematosus, hepatitis B virus-associated nephritis, malignancy-associated membranous nephropathy, etc.); 2. Combined with other primary glomerular diseases; 3. Acute kidney injury or stage 5 chronic kidney disease (eGFR 37.5°C, abnormal infection indicators); 5. History of malignant tumors or currently having malignant tumors; 6. Pregnant or breastfeeding women; 7. Received blood product transfusion within the past 3 months; 8. Having other autoimmune diseases; 9. Severe liver dysfunction (Child-Pugh class C); 10. Other conditions judged by the investigator as unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycosylation profiles of IgG population and subclasses (igg1-4); | — |
Countries
China
Contacts
Public ContactLiu Na
Shanghai East Hospital
Outcome results
None listed