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Optimal infusion rate of intravenous norepinephrine to prevent intraoperative hypotension in parturients undergoing cesarean delivery with spinal anesthesia for varying intra-abdominal pressures: a prospective dose-response trial

Optimal infusion rate of intravenous norepinephrine to prevent intraoperative hypotension in parturients undergoing cesarean delivery with spinal anesthesia for varying intra-abdominal pressures: a prospective dose-response trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600123124
Enrollment
Unknown
Registered
2026-04-22
Start date
2026-05-06
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intraoperative hypotension

Interventions

High intra-abdominal pressure group 1:Norepinephrine infusion rate (0.0µg/kg/min)
High intra-abdominal pressure group 2:Norepinephrine infusion rate (0.025µg/kg/min)
High intra-abdominal pressure group 3:Norepinephrine infusion rate (0.05µg/kg/min)
High intra-abdominal pressure group 4:Norepinephrine infusion rate (0.075µg/kg/min)
High intra-abdominal pressure group 5:Norepinephrine infusion rate (0.1µg/kg/min)
non high intra-abdominal pressure group1:Norepinephrine infusion rate (0.0µg/kg/min)
non high intra-abdominal pressure group2:Norepinephrine infusion rate (0.025µg/kg/min)
non high intra-abdominal pressure group3:Norepinephrine infusion rate (0.05µg/kg/min)
non high intra-abdominal pressure group4:Norepinephrine infusion rate (0.075µg/kg/min)
non high intra-abdominal pressure group5:Norepinephrine infusion rate (0.1µg/kg/min)

Sponsors

International Peace Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women aged 20-45 years, with a height of 155-170 cm, ASA grade II, full-term (gestational age >37 weeks), singleton cephalic presentation, scheduled for elective cesarean section.

Exclusion criteria

Exclusion criteria: Emergency cesarean section, placental abruption, twin pregnancy, pathological obesity (BMI>37.5), concomitant obvious cardiovascular disease, contraindication to spinal anesthesia, preeclampsia and gestational hypertension, allergy to ropivacaine, and refusal to participate in the study.

Design outcomes

Primary

MeasureTime frame
Systolic Blood Pressure;Norepinephrine half-maximal and effective infusion rate;

Secondary

MeasureTime frame
intra-abdominal pressure;Norepinephrine dosage;

Countries

China

Contacts

Public ContactMa Rui

International Peace Maternal and Child Health Hospital Anesthesiology Department

marui_merrygood@163.com+86 180 1731 0249

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026