Chronic postoperative pain
Conditions
Interventions
Experimental Group 4 (PI Group):Intravenous injection of the same amount of normal saline (placebo) + intercostal nerve block
Experimental Group 3 (PT Group):Intravenous injection of the same amount of normal saline (placebo) + paravertebral nerve block
Experimental Group 1 (ET Group):Intravenous injection of esketamine + paravertebral nerve block
Experimental Group 2 (EI Group):Intravenous injection of esketamine + intercostal nerve block
Sponsors
Henan Provincial People's Hospita,medical
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for radical lung cancer surgery; 2.The anesthesia method used was general anesthesia; 3.The operation lasted for more than one hour; 4.Age range: 18 - 80 years old; 5.ASA classification grades I - III; 6.Voluntary signing of the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Those who received radiotherapy or chemotherapy during the perioperative period; 2.Previous history of chest surgery; 3.Allergic reactions to the drugs used in this study; 4.Alcohol abuse, long-term use of opioid drugs or other painkillers; 5.History of opioid and analgesic drug use 3 months prior to the surgery; 6.Patients who had chronic pain before the operation; 7.BMI >=35kg/m^2; 8.Those with severe diseases of the heart and blood vessels; 9.Those with severe liver and kidney dysfunction; 10.Those with combined neurological disorders; 11.Those with combined mental disorders; 12.Those who have changed their surgical methods; 13.Those who were transferred to the intensive care unit after the surgery; 14.Emergency operation; 15. Uncontrolled hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep scores;Duration of indwelling of the drainage tube;The occurrence of depression;The number and function of NK cells, CD8+ T cells, CD4+ T cells, and the total number of lymphocytes;Chronic neuropathic pain;C-reactive protein;The dosage of propofol, remifentanil and vasoactive drugs used during the operation;Postoperative hospital stay;Remedy for pain relief situations;Is the acute pain trajectory an independent risk factor for the occurrence of chronic postoperative pain?;Incidence and severity score of postoperative nausea and vomiting;Whether pulmonary complications occurred after the surgery and the severity (grading) of these complications;NRS scores;Hemodynamic indicators; | — |
Countries
China
Contacts
Public Contactzhangwei
Henan Provincial People's Hospita,medical
Outcome results
None listed