Postoperative Delirium
Conditions
Interventions
DORA Group:From 1 day before surgery to the 3rd day after surgery, for a continuous 4 days, take Relebresen 5mg 1 hour before bedtime each night.
Placebo group:From 1 day before surgery to the 3rd day after surgery, for a total of 4 consecutive days, take 1 placebo pill 1 hour before bedtime each night.
Sponsors
Rui'an City People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years 2.No delirium at baseline as assessed by DSM-5 diagnostic criteria for delirium 3.ASA Physical Status Classification I–III 4.Elective surgery 5.Capable of cooperating with cognitive-delirium assessment preoperatively; with intact vision, hearing, and speech 6.Signed informed consent by the patient or legally authorized representative prior to enrollment
Exclusion criteria
Exclusion criteria: 1.Previous identical surgery 2.AUDIT-C score indicating high risk for alcohol withdrawal delirium 3.History of confirmed psychiatric disorders, epilepsy, or other active neurological diseases 4.Contraindications to dual orexin receptor antagonists 5.Inability to complete treatment, assessments, or other examinations for any reason 6.Currently participating in other clinical trials, or any condition judged by the investigator as interfering with this study 7.Any other condition deemed by the investigator as unsuitable for participation in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DSM-5, Delirium Diagnostic Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| 2014CAM-S; | — |
Countries
China
Contacts
Public ContactHuang Xuerong
Rui'an City People's Hospital
Outcome results
None listed