Myocardial function impairment occurs in patients with tumor cachexia
Conditions
Interventions
MT patients with cachexia:cachexia
simple MT patients:no cachexia
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–75 years, any gender, pathologically or cytologically confirmed malignant tumor (mainly tumor types prone to cachexia such as colorectal cancer, gastric cancer, lung cancer, etc.). 2. Research group: Meet the diagnostic criteria for tumor cachexia (refer to "Chinese Guidelines for Tumor Cachexia Diagnosis and Treatment (2023 edition)"), i.e., weight loss >=5% within 6 months (without intentional weight reduction), or body mass index (BMI) =18.5 kg/m^2, and no obvious symptoms such as loss of appetite or muscle atrophy. 4. Voluntarily accept myocardial function-related examinations (including cardiac ultrasound, myocardial enzyme profile, electrocardiogram, etc.) and cooperate with research data collection. 5. Sign a written informed consent form, have a certain level of communication ability, and be able to cooperate with follow-up (if short-term follow-up is involved).
Exclusion criteria
Exclusion criteria: 1.A history of primary heart diseases such as congenital heart disease, coronary heart disease, hypertensive heart disease, cardiomyopathy, valvular heart disease, or a past history of myocardial infarction and heart failure. 2.Complicated with other diseases that may affect myocardial function, such as severe hepatorenal failure, severe electrolyte imbalance, thyroid dysfunction, and diabetic cardiomyopathy; 3.Having received treatment with chemotherapeutic drugs with definite cardiotoxicity (such as anthracyclines and HER2 inhibitors), or having undergone thoracic radiotherapy (with the radiation field involving the heart) within the past 3 months. 4.Those with severe infection, coagulation dysfunction, mental illness, or cognitive impairment who are unable to cooperate with examinations and data collection. 5.Pregnant or lactating women (this population has special myocardial physiological status, and there are ethical risks associated with examinations and subsequent interventions); 6.Those with incomplete clinical data, inability to complete core examinations, or refusal to sign the informed consent form. 7.Those with an expected survival time of less than 1 months, critical illness, or inability to tolerate the research procedures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ejection factor; | — |
Countries
China
Contacts
Public ContactYichao Wang
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed