None
Conditions
Interventions
Remimazolam group:Collect blood samples from patients at different time points
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years (inclusive), regardless of gender; 2. Patients scheduled for elective general anesthesia for thoracic surgery with a hospital stay of =3 days; 3. Expected surgical duration of 1 to 2 hours; 4. ASA physical status classification of I or II; 5. Body mass index (BMI) between 18 kg/m^2 and 30 kg/m^2 (exclusive of the boundaries); 6. Fully understand the study, voluntarily participate, and personally sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergy to benzodiazepines; 2. Severe respiratory diseases (including acute respiratory infections); 3. Acute heart failure; 4. Moderate to severe valvular heart disease; 5. Psychiatric disorders, long-term use of psychotropic medications, or cognitive dysfunction; 6. Abnormalities in liver, kidney, or coagulation function; 7. History of benzodiazepine use, substance abuse, or alcohol abuse within 2 years prior to the screening period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentrations of remimazolam at different time points ; | — |
Countries
China
Contacts
Public ContactWu Jingxiang
Shanghai Chest Hospital
Outcome results
None listed