None
Conditions
Interventions
Group A (Lidocaine 1.5 mg/kg/h maintenance group):a. Before anesthesia induction, administer an intravenous bolus of lidocaine at 1.5 mg/kg (based on ideal body weight) over more than 10 minutes.
b. S
Group B (Lidocaine 2.5 mg/kg/h maintenance group):a. Before anesthesia induction, administer an intravenous bolus of lidocaine at 1.5 mg/kg (based on ideal body weight) over more than 10 minutes.
b. S
Group C (normal saline group):An equal volume of normal saline administered during anesthesia induction and intraoperative maintenance.
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-65 years old; 2. American Society of Anesthesiologists (ASA) classification I-III; 3. Patients undergoing elective thoracoscopic lung resection (wedge resection, lobectomy, or segmentectomy) under general anesthesia; 4. BMI between 18 kg/m^2 and 28 kg/m^2; 5. Surgery duration 2–6 hours; 6. The subjects have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Arrhythmia or systolic heart failure: second- or third-degree atrioventricular block, EF <50%; 2. Severe liver dysfunction: AST, ALT, or bilirubin greater than 2.5 times the upper limit of normal; 3. Severe renal dysfunction: creatinine clearance less than 60 ml/min; 4. Presence of metastasis to other organs; 5. Allergy to any experimental drug; 6. Chronic pain or long-term use of opioid drugs; 7. Mental illness, communication barriers, or inability to understand the Numeric Rating Scale (NRS) for pain; 8. History of asthma or patients with preoperative examinations suggesting possible asthma; 9. Pregnant or breastfeeding women; 10. Refusal to receive lidocaine infusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Recovery Quality QoR-15 Score;Duration of the patient's stay in the post-anesthesia care unit;From surgery until hospital discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events of the investigational drug;NRS pain scores at rest and during movement (coughing) within 48 hours postoperatively;Perioperative opioid consumption;The incidence of postoperative nausea and vomiting (PONV) within 48 hours postoperatively;Time to tracheal extubation; | — |
Countries
China
Contacts
Public ContactXie Haihui
Dongguan People's Hospital
Outcome results
None listed