Stroke
Conditions
Interventions
Active tDCS group:On the basis of conventional rehabilitation, the subjects receive anodal transcranial direct current stimulation (tDCS) over the right primary somatosensory cortex (RS1). The stimula
Sham tDCS group:On the basis of conventional rehabilitation, the subjects receive sham tDCS over the right primary somatosensory cortex (RS1). The electrode configuration and duration (20 minutes) are
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. All the patients with cerebrovascular disease who met the diagnostic criteria of "Key points for the Diagnosis of Various Cerebrovascular Diseases" (1996) revised by the Fourth National Academic Conference on Cerebrovascular Disease were confirmed by head CT or MRI scan, and their conditions were relatively stable within 5-14 days after onset; 2. Age 60-80 years old, both sexes; 3. Initial stroke, clear consciousness, GCS score > 12, good compliance with Mini-mental state examination (MMSE), able to understand mouth breathing and Borg scoring instructions; 4. In right-handed patients with left cerebral hemisphere stroke (right-sided limb paralysis/sensory disturbance, but the right cerebral hemisphere is relatively intact), or in patients with small-area stroke without cortex involvement, RS1 structure is relatively intact; 5. No history of respiratory and pulmonary diseases; 6. No history of mental disorders; 7. Informed consent was signed.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cognitive impairment could not cooperate with the cough reflex test; 2. Use of ACEI, bronchodilators, hormones, antihistamines and antitussive drugs in the past 4 weeks; 3. Metallic implants in the body; 4. Alcoholics or drug addicts; 5. Hypersensitivity to stimulation site; 6. History of epilepsy: patients with previous history of seizures or severe abnormal discharge on electroencephalogram; 7. Absolute or relative contraindications of tDCS: skull defect, scalp damage or infection at the stimulation site, metal implants (such as cardiac pacemaker, cerebral aneurysm clip, cochlear implant, etc.); 8. Patients with acute cerebral infarction with hemorrhagic transformation indicated by head imaging (CT/MRI), or with severe cerebral microbleeds burden (multiple old microbleeds, number >10) indicated by SWI/T2 sequence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough reflex threshold;Urge-to-cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;Electroencephalogram data; | — |
Countries
China
Contacts
Public ContactGui Peijun
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed