Patients with intermediate-to-high risk differentiated thyroid cancer who have undergone total/near-total thyroidectomy
Conditions
Interventions
The moderate-dose adjuvant therapy group and the high-dose adjuvant therapy group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histopathologically confirmed papillary thyroid carcinoma or follicular thyroid carcinoma; 2. Patients of any age or gender; 3. Underwent adjuvant iodine-131 therapy meeting at least one of the following criteria: (1) Primary tumor T4 stage; (2) Presence of soft tissue invasion; (3) Cervical lymph node metastasis =3 cm and/or with extranodal extension; (4) Thyroglobulin (Tg) level >10 ng/ml under TSH-stimulated conditions.
Exclusion criteria
Exclusion criteria: 1. Incomplete resection of the tumor lesion; 2. Known presence of local or distant metastasis; 3. Postoperative TSH-stimulated Tg levels highly suggestive of concurrent distant metastasis; 4. Positive TgAb (thyroglobulin antibody) status; 5. Concurrent receipt of other anti-tumor therapies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-inferiority Rate (non-IR);Structural Recurrence-Free Survival (RFSstructural); | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfactory Efficacy Rate (ER);Biochemical Recurrence-Free Survival (RFSbiochemical); | — |
Countries
China
Contacts
Public ContactWang Renfei
Shanghai Tenth People's Hospital
Outcome results
None listed