Sex Differences in Risk Factors and Population Attributable Risk of Early-Onset Coronary Heart Disease: A Single-center Matched Case-control Study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600123084

Enrollment

Unknown

Registered

2026-04-21

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary heart disease

Interventions

Early-onset Coronary Heart Disease Group:None

Non-cardiovascular Metabolic Disease Control Group:None

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Case Group 1. Aged 18 to 55 years old. 2. Confirmed by coronary angiography (CAG) or coronary CTA examination. Confirmed diagnosis definition: At least one major epicardial coronary artery (left main trunk, anterior descending branch, circumambulation branch, right coronary) has a lumen diameter stenosis of >=50%. Control Group 1. Aged 18 to 55 years old. 2. The electrocardiogram upon admission was normal, and there was no chest pain symptom.

Exclusion criteria

Exclusion criteria: Case Group 1. Combined severe hepatic or renal dysfunction (ALT/AST >= 3 times the upper limit of normal, or eGFR < 30 ml/min/1.73 m^2) 2. Combined advanced malignancy, mental disorders, cognitive impairment, and other diseases 3. Patients with incomplete clinical data Control Group 1. History of coronary heart disease, stroke, heart failure, or peripheral arterial disease 2. Patients admitted with primary diagnoses of type 2 diabetes mellitus, hypertensive emergency, or hyperlipidemia 3. Patients with incomplete clinical data 4. Combined advanced malignancy, mental disorders, cognitive impairment, and other diseases

Design outcomes

Primary

Measure	Time frame
Demographic and baseline characteristics (age, sex, marital status, ethnicity, education level, smoking history, alcohol consumption);Comorbidities history (hypertension, diabetes mellitus, atrial fibrillation, dyslipidemia, myocardial infarction, heart failure, stroke/transient ischemic attack (TIA), deep vein thrombosis, chronic kidney disease, chronic liver disease, etc.);Physical examination and auxiliary tests (height, weight, waist circumference, heart rate, blood pressure, laboratory tests including liver function, lipid profile, renal function, urine protein-to-creatinine ratio, electrocardiogram, ultrasound, CT, etc.);	—

Measure

Time frame

Demographic and baseline characteristics (age, sex, marital status, ethnicity, education level, smoking history, alcohol consumption);Comorbidities history (hypertension, diabetes mellitus, atrial fibrillation, dyslipidemia, myocardial infarction, heart failure, stroke/transient ischemic attack (TIA), deep vein thrombosis, chronic kidney disease, chronic liver disease, etc.);Physical examination and auxiliary tests (height, weight, waist circumference, heart rate, blood pressure, laboratory tests including liver function, lipid profile, renal function, urine protein-to-creatinine ratio, electrocardiogram, ultrasound, CT, etc.);

—

Countries

China

Contacts

Public ContactHuang Rongchong

Beijing Friendship Hospital ,Capital Medical University

rchuang@aliyun.com+86 10 63138217

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026