Post-traumatic sepsis complicated by critical illness polyneuropathy (CIP)
Conditions
Interventions
Post-traumatic sepsis(Case group):None
Simple trauma, no sepsis(Control group):None
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Inclusion Criteria for the Case Group: (1)Age =18 years, with no restriction on sex; (2)Hospitalized for severe trauma and requiring lower-limb amputation; (3)Clinically diagnosed with post-traumatic sepsis. (4)The diagnosis of sepsis will be based on generally accepted clinical diagnostic criteria and determined comprehensively by the attending physician according to evidence of infection, organ dysfunction, and other relevant clinical data; Discarded sciatic nerve tissue, remote from the direct injury site and adequate for testing, can be obtained intraoperatively; (5)The patient or his/her legally authorized representative has signed a written informed consent form agreeing to the use of discarded surgical tissue for this study. 2.Inclusion Criteria for the Control Group: (1)Age =18 years, with no restriction on sex; (2)Hospitalized for severe trauma and requiring lower-limb amputation; (3)No definite diagnosis of sepsis during hospitalization; (4)Discarded sciatic nerve tissue, remote from the direct injury site and adequate for testing, can be obtained intraoperatively; (5)The patient or his/her legally authorized representative has signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a clearly documented history of peripheral nervous system disorders, such as hereditary peripheral neuropathy or chronic inflammatory demyelinating polyradiculoneuropathy; 2.Patients with severe central nervous system injury, such as severe traumatic brain injury or spinal cord injury, which may significantly affect the assessment of neurological function; 3.Patients with pre-existing diseases known to affect peripheral nerve status, such as severe diabetic peripheral neuropathy or alcohol-related peripheral neuropathy; 4.Patients in whom the sciatic nerve in the amputated specimen is severely damaged, necrotic, or contaminated, making it impossible to obtain a qualified study specimen; 5.Patients with severely incomplete clinical data, making collection of major study variables impossible; 6.Patients or their legally authorized representatives who refuse to participate in the study, or who withdraw informed consent during the course of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of Schwann cell metabolism-related molecules, such as SDHB, PGC-1a, etc.;Levels of metabolites such as succinate in sciatic nerve tissue;Macrophage infiltration degree and inflammation phenotype-related indicators;SUCNR1 expression level;Changes in neural tissue structure; | — |
Countries
China
Contacts
Public ContactWang Yan
Army Medical Center of PLA
Outcome results
None listed