Moderate to Severe Traumatic Brain Injury
Conditions
Interventions
Multimodal Monitoring Group:Insert ICP probe during surgery, monitor CPP, cerebral oxygenation (NIRS), brain temperature, and TCD postoperatively, record sedation and analgesia depth using BIS
implement interventions (including hypothermia therapy) based on ICP, CPP, cerebral oxygenation, brain temperature, and TCD
ICP Monitoring Group:Insert ICP probe during surgery, monitor CPP and ICP within 24 hours postoperatively, implement interventions based on ICP and CPP, record sedation and analgesia depth using BIS
Sponsors
Changzhou No.2 People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 18 years old.; 2. Admitted to the hospital due to non-penetrating craniocerebral trauma and implanted with an intracranial pressure probe.; 3. Preoperative GCS score <=12 points without sedation and analgesia.; 4. All patients were diagnosed by cranial CT examination upon admission.
Exclusion criteria
Exclusion criteria: 1. Patients with an estimated total hospital stay of no more than 2 days. 2. Preoperative GCS score =3 points, or fixed and dilated pupils. 3. Before this injury, due to various conditions such as trauma, spinal cord diseases, stroke, etc., the patient's original limb movement, language function, etc. were already restricted, such as hemiplegia, unclear speech, etc., affecting the patient's functional score.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival situation;Postoperative GOS scores at 1, 3, and 6 months;Postoperative BI scores at 1, 3, and 6 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay;Total hospitalization length of stay;Complications;Mechanical ventilation duration;Tracheostomy;Sedative duration;Analgesic duration;Use of lytic cocktail;Total hospitalization costs;Reoperation; | — |
Countries
China
Contacts
Public ContactLiu Fang
Changzhou No.2 People’s Hospital
Outcome results
None listed