obesity
Conditions
Interventions
Healthy control group:None
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Obese group 1.Aged 18-65 years (inclusive), regardless of gender or ethnicity. 2.Diagnosed with primary obesity and BMI =28 kg/m². 3.No use of weight-loss medications or metabolic surgery or other weight intervention measures within the past 3 months. 4.Provided voluntary written informed consent. Healthy control group 1. Aged 18-65 years (inclusive); no restrictions on gender or ethnicity; 2. Healthy individuals with a body mass index (BMI) between 18.5-23.9 kg/m²; excludes those with obvious acute or chronic diseases, recent medication use, or abnormal diet; 3. Assessed by the researcher as suitable to participate in this study; 4. Voluntarily willing to participate in the clinical trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Obese group 1.Exclude subjects with secondary obesity. 2.Concurrent severe medical conditions or unstable chronic diseases. 3.Pregnant or lactating women, or those planning pregnancy. 4.Active malignancy, severe psychiatric disorders, or other conditions that may affect compliance. 5.Antibiotic use within 2 weeks prior to screening. 6.Participation in another interventional clinical trial within 4 weeks prior to screening; 7.Any other condition that, in the investigator's judgment, would make the subject unsuitable for participation in the study. Healthy control group 1. Combined with other severe organic diseases or the disease is in the acute attack phase; 2. Participated in other interventional clinical trials (including drugs, nutritional preparations, medical devices, etc.) within 4 weeks before screening; 3. Other conditions that the investigator believes are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight;Waist Circumference;Body composition;Serum Metabolomic Characteristics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete Blood Countand C-Reactive Protein;Blood Biochemistry;Gut microbiota;Glucose;Serum Insulin;Serum Lipid Profile and Serum Uric Acid; | — |
Countries
China
Contacts
Public ContactHong Cao
Affiliated Hospital of Jiangnan University
Outcome results
None listed