major depressive disorder, MDD
Conditions
Interventions
MDD Patiets:Treatment with escitalopram
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-55 years old; 2. MDD patients who meet DSM-5 diagnostic criteria; 3. Montgomery Depression Rating Scale score >=20. 4. Young's Manic State Rating Scale score <=14; 5. The body mass index is between 18.5 and 29.5 kg/m^2; 6. No contact with other psychotropic drugs in the last 30 days; 7. The patient or guardian agrees to the treatment and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Serious systemic diseases (such as heart, liver, renal insufficiency, etc.) may have life and health risks during the study period; 2. Complicated with other severe neuropsychiatric diseases (such as schizophrenia) or developmental retardation; 3. Pregnant/lactating women; 4. Item 10 of Montgomery Depression Scale > =4. 5. Substance abuse or alcoholism; 6. Recent (within 3 months) history of brain trauma or brain surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MADRS reduction rate;blood concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG;Cognitive level;outcomes of YMRS;outcomes of HDMD;outcomes of HAMD;Genotyping;outcomes of TESS; | — |
Countries
China
Contacts
Public ContactChunxiao Dai
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Outcome results
None listed