Slow-transit constipation (STC)
Conditions
Interventions
Pre+Post-op Fish Oil PN Group:N/A
Post-op Only Fish Oil PN Group:N/A
Sponsors
Shandong Provincial Qianfoshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 to 75 years. 2. Meets diagnostic criteria for slow-transit constipation (STC) or megacolon and is scheduled for elective colon surgery. 3. Nutritional Risk Screening 2002 (NRS2002) score >=3. 4. Receives fish oil-containing parenteral nutrition (PN) for >=3 days preoperatively or initiates PN for the first time postoperatively (according to the study cohort definition). 5. Voluntarily participates in the study and provides signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Mental disorders or other conditions that prevent cooperation with treatment or follow-up. 2. Pregnant or breastfeeding women, women planning pregnancy / in a pre-pregnancy state, or women with a clear intention to become pregnant during the perioperative period or follow-up. 3. Contraindications to surgery or parenteral nutrition. 4. Concurrent enrollment in another study. 5. No baseline data available before initiation of nutritional support treatment. 6. Any other condition judged by the investigator to make the participant unsuitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative complication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative length of hospital stay;Adverse events (AEs);Laboratory safety monitoring for hepatic and renal function (bilirubin and creatinine);Perioperative nutritional status changes (BMI, prealbumin, albumin, and retinol-binding protein);Postoperative gastrointestinal function recovery indicators (time to first flatus, time to first defecation, and defecation frequency during hospitalization);Improvement in quality of life (PAC-QOL score);Perioperative inflammatory status changes (CRP, IL-6, and systemic immune-inflammation index [SII]);Initial screening for intestinal complications (imaging assessment: abdominal plain X-ray);Improvement in constipation (Wexner score);Psychological status (Self-Rating Anxiety Scale, SAS);Adverse drug reactions related to study nutritional support (ADRs);Dysuria status and sexual function scores (OABSS, FSFI/IIEF-5); | — |
Countries
China
Contacts
Public ContactChen Jingbo
Shandong Provincial Qianfoshan Hospital
Outcome results
None listed