Postoperative analgesia
Conditions
Interventions
non-elderly group:Intravenous propofol and oliceridine were administered to induce moderate to deep sedation, with each drug delivered within 30+/-5 seconds. The induction dose of propofol was 0.5mg/k
if the previous patient exhibited a positive response, the next patient received a higher dose gradient. The initial dose was set at 0.04 mg/kg, and the adjacent dose?gradient ratio was 1.1.
elderly group:Intravenous propofol and oliceridine were administered to induce moderate to deep sedation, with each drug delivered within 30+/-5 seconds. The induction dose of propofol was 0.5mg/kg. T
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Gender is not restricted. Non-elderly group: age >= 18 and = 65 years old; 2. Body Mass Index (BMI) >= 18 and = 60 and = 90 mmHg and = 60 mmHg and = 92%.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hemodynamic instability (requiring > 0.5 µg/kg/min of norepinephrine equivalent to maintain MAP >= 65 mmHg, or frequent malignant arrhythmias); 2. Patients with drug allergies to the investigational drug, such as propofol and its excipients, or allergies to opioid drugs like fentanyl and remifentanil; 3. Patients with contraindications to opioid drugs, such as bronchial asthma or acute intestinal obstruction; 4. Patients with neurological diseases or a history of mental illness who cannot accurately assess the level of sedation; 5. Patients with severe liver dysfunction (Child-Pugh C grade), or chronic renal failure with eGFR <= 29 ml/min/1.73 m^2 (or undergoing maintenance hemodialysis/pod hemodialysis); 6. Patients who have been using analgesic drugs for a long time, or who used long-acting analgesic drugs before the study; 7. Patients who have been using psychotropic drugs for a long time; 8. Other situations that the researchers consider unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median effective dose of oliceridine combined with propofol for inhibiting responses to fiberoptic bronchoscopy in young and elderly patients in the ICU; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depth of sedation;HR;blood pressure;SpO2;The duration of deep sedation during induction; | — |
Countries
China
Contacts
Public ContactXie Keliang
Tianjin Medical University General Hospital
Outcome results
None listed