Social impairments and restricted, repetitive behaviors in children with Autism Spectrum Disorder (ASD)
Conditions
Interventions
Autism Spectrum Disorder (ASD) Group:None
Typical Development (TD) Control Group:None
Sponsors
The Fifth Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the autism group: (1) Confirmation of ASD diagnosis by a rehabilitation department attending physician according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria; (2) Meeting the ASD diagnostic threshold on the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2); (3) Age between 2 and 12 years; (4) No use of any psychotropic medication within the past 3 months; (5) Both the child and parents/guardians provided written informed consent to participate in the study. 2. Inclusion criteria for the control group: (1) Exclusion of ASD diagnosis based on assessment with the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2); (2) Age between 2 and 12 years; (3) No use of any psychotropic medication within the past 3 months; (4) Both the child and parents/guardians provided written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Presence of focal or diffuse intracranial lesions; 2. History of severe systemic diseases, neurological disorders, or traumatic brain injury; 3. History of alcohol or substance abuse or dependence; 4. Presence of metal implants in the body, including non-removable dentures; 5. Inability to cooperate and complete the examination due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD).;Autism Diagnostic Observation Schedule, Second Edition (ADOS-2);Shannon index; Bray-Curtis distance; Observed OTUs/ASVs; PERMANOVA analysis.;Social Responsiveness Scale (SRS);6-Item Gastrointestinal Symptom Index (6-GSI);Concentration of short-chain fatty acids (SCFAs); | — |
Countries
China
Contacts
Public ContactFeng Pengya
The Fifth Affiliated Hospital of Zhengzhou University
Outcome results
None listed