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Longitudinal Trajectories of Frailty and Cognitive Impairment in Older Breast Cancer Patients Receiving Chemotherapy: Associated Factors and Predictors

Longitudinal Trajectories of Frailty and Cognitive Impairment in Older Breast Cancer Patients Receiving Chemotherapy: Associated Factors and Predictors

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123029
Enrollment
Unknown
Registered
2026-04-21
Start date
2026-04-26
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Interventions

Observation group:None

Sponsors

The Second Norman Bethune Hospital of Jilin University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
45 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Female, age >= 45 years; 2. Diagnosed with invasive breast cancer according to the "Breast Cancer Diagnosis and Treatment Guidelines" (2022 edition); 3. Receiving adjuvant chemotherapy or neoadjuvant chemotherapy for the first time with therapeutic intent; 4. Patient is conscious and able to communicate in writing and verbally; 5. Expected survival >= 1 year.

Exclusion criteria

Exclusion criteria: 1.Definite history of stroke, Parkinson's disease, epilepsy, multiple sclerosis, severe traumatic brain injury, or any other known neurological disorder that may cause cognitive impairment. 2.Complicated with brain tumor or brain metastasis; history of intracranial radiotherapy, prior radiotherapy/chemotherapy, or brain surgery/trauma. 3.Presence of severe frailty (e.g., FRAIL scale score >=4) or diagnosed dementia / moderate-to-severe cognitive impairment (MoCA <26 for preliminary screening) at baseline assessment (T0). 4.Receiving psychopharmacological and/or psychological treatment. 5.Presence of visual, hearing, speech, or limb function abnormalities.

Design outcomes

Primary

MeasureTime frame
Frailty;Cognitive ;

Secondary

MeasureTime frame
Social Support;Depression;Anxiety;Self-management efficacy;Activity;Sleep Quality;Nutritional Status;

Countries

China

Contacts

Public ContactGuo Xinrong

The Second Norman Bethune Hospital of Jilin University

guoxr@jlu.edu.cn+86 155 2689 1949

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026