None listed
Conditions
Interventions
Acute Hyperbaric Oxygen-Hypobaric Oxygen Crossover Group:First Hyperbaric Oxygen Multi-Stage Exposure Followed by Hypobaric Multi-Stage Exposure
Acute Hypobaric Oxygen-Hyperbaric Oxygen Crossover Group:First Hypobaric Multi-Stage Exposure Followed by Hyperbaric Oxygen Multi-Stage Exposure
Chronic Hyperbaric Oxygen Exposure Group:Chronic Hyperbaric Oxygen Exposure
Chronic Hypobaric Oxygen Exposure Group:Chronic Hypobaric Oxygen Exposure
Sponsors
Shanghai Yangzhi rehabilitation hospital
Eligibility
Sex/Gender
All
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age 25-35 years old, with balanced gender distribution; 2. Self-reported good health, with no obvious diseases of the cardiovascular, respiratory, nervous, or hematological systems in physical examination; 3. First-time entry into a hyperbaric oxygen chamber or first-time exposure to hypobaric/plateau simulation; no history of plateau exposure (=2500m, =3 days) or hyperbaric exposure in the past 1 month; 4. Normal otolaryngological examination, able to perform ear pressure equalization, and assessed by the study physician to safely complete pressure increase/decrease; 5. Normal auditory and visual functions, able to understand and cooperate with the completion of cognitive tasks, EEG, and fNIRS tests; 6. Agree to complete two in-chamber visits, 1 week of washout, and (if transferred) 20 long-term exposures over 4 weeks in accordance with the protocol; 7. Sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of epilepsy, syncope, unexplained loss of consciousness, or organic lesions of the central nervous system; 2. Acute upper respiratory tract infection, otitis media, sinusitis, or inability to perform ear pressure equalization; 3. Females who are pregnant, breastfeeding, or planning to become pregnant in the near future; 4. Individuals with claustrophobia or psychological conditions that make them unsuitable for entering a closed chamber; 5. Use of medications affecting neurophysiological function, ear pressure equalization, or the cardiovascular system within 2 weeks prior to enrollment (see main text for the specific medication list); 6. Participation in other interventional clinical studies within 1 month; 7. Individuals judged by the researcher to be unable to complete the entire trial process as scheduled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fNIRS indicators: peak and area of frontal/parietal lobe HbO and HbR in task state;Reaction time and accuracy during the cognitive task;EEG signal; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral Physiology: SpO2, HR, HRV, BP;MRI Structural/Functional Imaging; | — |
Countries
China
Contacts
Public ContactJin Lingjing
Shanghai Yangzhi rehabilitation hospital
Outcome results
None listed