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Clinical Characteristics, Risk Prediction, and Prognostic Comparison of Acute Exacerbation of Interstitial Lung Disease Induced by Infectious versus Non-Infectious Triggers

Acute Exacerbation of Interstitial Lung Disease: A Comparison of Clinical Characteristics, Risk Prediction, and Prognosis Between Infectious and Non-Infectious Cases — An Observational Study - AE-ILD: A Comparison of Clinical Characteristics, Risk Prediction, and Prognosis Between Infectious and Non-Infectious Cases — An Observational Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600123015
Enrollment
Unknown
Registered
2026-04-21
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interstitial Lung Disease

Interventions

Infection Group/Non-infection Group:None

Sponsors

Nanjing Drum Tower Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Hospitalized patients aged 18-80 years, diagnosed with AE-ILD between January 1, 2021, and January 1, 2026. 2. Patients diagnosed with ILD according to the 2013 American Thoracic Society/European Respiratory Society (ATS/ERS) official statement, and concurrently meeting the AE-ILD diagnostic criteria extended from the 2016 ATS/ERS guidelines on acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). 3. Cases were jointly determined as infectious or non-infectious by two attending physicians (or higher) from the Respiratory Department. 4. Possessing complete inpatient medical records, laboratory data, imaging data, and at least 180 days of follow-up information.

Exclusion criteria

Exclusion criteria: 1. Complicated with active malignant tumors, end-stage liver or kidney failure, primary immunodeficiency diseases, HIV infection, or post-organ transplant status. 2. Pregnant or breastfeeding women. 3. Acute respiratory failure caused by other triggers such as trauma, pneumothorax, pulmonary embolism, or heart failure. 4. Severe lack of clinical data, where key differential indicators (e.g., chest imaging, etiological results) are unavailable.

Design outcomes

Primary

MeasureTime frame
Clinical Outcomes;Area under the ROC curve;

Secondary

MeasureTime frame
Etiological indicators;Laboratory indicators;Symptomatology;Pulmonary function;

Countries

China

Contacts

Public ContactSu Xin

Nanjing Drum Tower Hospital

suxinjs@163.com+86 186 2600 6870

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026