Schizophrenia
Conditions
Interventions
First-episode drug-naive schizophrenia patients (patient group):None
Healthy controls:None
Sponsors
The Second People's Hospital of Yibin
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the patient group: (1) Diagnosis meets the DSM-5 criteria for schizophrenia. Patients are first-episode and have taken any psychiatric medication for no more than 3 days; (2) Aged between 16 and 55 years; (3) Han ethnicity; (4) Primary residence in the Chengdu area for the past 6 months; (5) Voluntary participation in this study with signed written informed consent. 2. Inclusion criteria for the healthy control group: (1) Resided in Southwest China for the past 6 months; (2) Aged between 16 and 55 years; (3) Han ethnicity; (4) No history of major surgery within the past 3 years; (5) Intact social functioning and full capacity for civil conduct.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the patient group: (1) History or current presence of other mental disorders besides schizophrenia (such as intellectual disability, bipolar disorder, depression, etc.); (2) History or current presence of definite organic brain diseases; (3) Currently suffering from somatic diseases receiving any oral medication, or chronic diseases requiring long-term medication, such as diabetes, systemic lupus erythematosus, and hypertension; (4) Infectious digestive system diseases (such as bacterial enteritis, dysentery, intestinal tuberculosis, etc.) within the past 1 month; (5) Use of antibiotics, probiotics, prebiotics, etc. within the past 1 month; (6) Women in pregnancy or perinatal period within the past 1 year; (7) Unable to cooperate with testing, refusing to participate in this study, or withdrawing informed consent. 2. Exclusion criteria for the healthy control group: (1) History or current presence of any mental disorder; (2) History or current presence of definite organic brain diseases; (3) Currently suffering from somatic diseases receiving any oral medication, or chronic diseases requiring long-term medication, such as diabetes, systemic lupus erythematosus, and hypertension; (4) Infectious digestive system diseases (such as bacterial enteritis, dysentery, intestinal tuberculosis, etc.) within the past 1 month; (5) Use of antibiotics, probiotics, prebiotics, etc. within the past 1 month; (6) Unable to cooperate with testing, refusing to participate in this study, or withdrawing informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale (PANSS) Score;Relative Abundance of Dominant Gut Microbiota;Relative Concentration of Small Molecule Metabolites;Concentration of Short-Chain Fatty Acids;Dietary Pattern;Food Craving Intensity;Routine Inflammatory Markers (White Blood Cell Count, C-Reactive Protein, Interleukins, etc.); | — |
Countries
China
Contacts
Public ContactWang Li
The Second People's Hospital of Yibin
Outcome results
None listed