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Mechanism of Jianpi Huoxue Formula Inducing Polarization of Liver Macrophages Against Liver Fibrosis

Mechanism of Jianpi Huoxue Formula Based on LncRNA GAS5/miR-23a/PTEN/AKT Axis Inducing Polarization of Liver Macrophages Against Liver Fibrosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122995
Enrollment
Unknown
Registered
2026-04-20
Start date
2024-04-28
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Fibrosis

Interventions

Control Group:Conventional Western medicine for liver protection treatment
Traditional Chinese Medicine Group:Jianpi huoxue decoction

Sponsors

The First Affiliated Hospital of Anhui University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.The patient meets the diagnostic criteria for portal hypertension in cirrhosis; 2.The etiology of liver cirrhosis is clearly defined as hepatitis B or hepatitis C virus; 3.No serious cardiovascular or coagulation disorders; 4.Expected survival time of more than 12 months; 5. Voluntarily joined the study and signed the informed consent form;

Exclusion criteria

Exclusion criteria: 1.Patients with unclear preoperative diagnosis of liver cirrhosis etiology; 2.Patients with severe cardiovascular or coagulation disorders; 3.Patients with poor compliance, early postoperative transfer or external treatment without strict follow-up records; 4.Individuals with severe mental illness;

Design outcomes

Primary

MeasureTime frame
Liver fibrosis indexes (hyaluronic acid (HA), laminin (LN), procollagen type ? (PC - ?), collagen type ? (? - C));

Secondary

MeasureTime frame
Liver function indexes: albumin (ALB), total bilirubin (TBIL), aspartate aminotransferase (AST), alanine aminotransferase (ALT);

Countries

China

Contacts

Public ContactLong Huang

The First Affiliated Hospital of Anhui University of Chinese Medicine

huanglongtest@163.com+86 13856977063

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026