Alpha-thalassemia
Conditions
Interventions
Inspection Team:Non invasive detection of severe alpha thalassemia
Sponsors
Guangdong Women and Children Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Both parents are SEA thalassemia carriers; 2.Gestational age > 12 weeks; 3.No other indications for prenatal diagnosis; 4.Willing to provide informed consent and enroll in the study.
Exclusion criteria
Exclusion criteria: 1.Not both spouses are SEA thalassemia carriers, or refusal to enroll; 2.Inability to obtain adequate and valid samples for any reason; 3.Blood transfusion within six months for any reason; 4.Any other conditions deemed unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| positive concordance rate;Negative concordance rate;Kappa score; | — |
Countries
China
Contacts
Public ContactAihua Yin
Guangdong Women and Children Hospital
Outcome results
None listed