Postoperative sleep disorder
Conditions
Interventions
intervention group:Using standard treatment parameters, the frequency of the Transcutaneous Auricular Vagus Nerve Stimulation device was set to 25 Hz, the pulse width was 250 µs, and the current inten
control group:Using low-frequency treatment parameters, the frequency of the Transcutaneous Auricular Vagus Nerve Stimulation device was set to 1 Hz, the pulse width was 250 µs, and the current inten
Sponsors
Beijing Jishuitan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 65 and 75 years old, with ASA classification of I-III; 2. Planned to undergo elective single-segment or double-segment posterior lumbar interbody fusion surgery (TLIF); expected operation time >= 2 hours; postoperative hospital stay >= 4 days; 3. Patients without sleep disorders before the surgery: PSQI = 6; 4. Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Neurosurgery or cardiac surgery or injury to the cervical vagus nerve or history of surgery; 2. Preoperative severe cognitive dysfunction affecting perioperative cognitive function assessment (e.g., MMSE < 24); 3. Terminal diseases with an expected survival period of less than 6 months; 4. Emergency surgery within 6 hours after admission; 5. Endocrine system diseases (such as Cushing's syndrome, uncontrolled hyperthyroidism/hypothyroidism); 6. Continuous use of drugs that affect melatonin, cortisol secretion or HRV for more than 1 month (such as exogenous glucocorticoids, beta-blockers, melatonin supplements, specific psychotropic drugs); 7. Severe liver or kidney dysfunction (e.g., eGFR < 30 mL/min or Child-Pugh C grade); 8. Skin damage/infection in the auricular region; 9. Severe sinus bradycardia, second-degree or higher AVB, pacemaker implantation or severe arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence rate (percentage) of sleep disorders on the 4th day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Melatonin rhythm;Cortisol rhythm;Sleep bracelet sleep monitoring parameters;Resting/Moving State VAS Score;Cognitive and Delirium Assessment;Postoperative nausea and vomiting score;TNF-a;IL-6; | — |
Countries
China
Contacts
Public ContactChen Chen
Beijing Jishuitan Hospital, Capital Medical University
Outcome results
None listed