Crohn's disease
Conditions
Interventions
Case (unresponsive) group:None
Control (response ) group:None
Sponsors
Suzhou Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age over 18 years old, gender not limited. 2) Diagnosed with Crohn's disease (according to WHO diagnostic criteria). 3) Patients with moderate to severe active Crohn's disease who have experienced insufficient response, loss of response, or intolerance to traditional or biologic treatments in the past. 4) Capable and willing to provide written informed consent and cooperate with research visits and sample collection.
Exclusion criteria
Exclusion criteria: 1) Relapse is caused by clear infection (such as Clostridium difficile, CMV), use of nonsteroidal anti-inflammatory drugs, or simple obstructive symptoms caused by intestinal stenosis. 2) Plan to use other systemic immunosuppressants or biologics in combination during re induction therapy (allowing for stable doses of aminosalicylic acid preparations). 3) It has been confirmed in the past that there is no response or severe allergic reaction to gusetuximab. 4) Pregnant or lactating women(or planning for pregnancy). 5) There are serious extraintestinal manifestations, active malignant tumors or serious infections (such as herpes virus, hepatitis B, hepatitis, tuberculosis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal mucosal tissue; | — |
Countries
China
Contacts
Public ContactWen Ke
Suzhou Traditional Chinese Medicine Hospital
Outcome results
None listed