Postoperative delirium
Conditions
Interventions
Postoperative delirium group and non-operative delirium group (Sample size per group depends on postoperative follow-up):None
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. American Society of Anesthesiologists Physical Status (ASA) I-III; 3. Scheduled to undergo major laparoscopic abdominal surgery under general anesthesia (including colorectal cancer resection, radical surgery, ovarian cancer staging, endometrial cancer radical surgery, cervical cancer radical surgery, myomectomy, etc.); 4. Voluntary participation in this study and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing neuropsychiatric disorders such as schizophrenia, Parkinson's disease, epilepsy, or dementia, long-term use of psychiatric medications (e.g., antidepressants, antipsychotics), or a history of alcohol abuse within the recent past (1 month); 2. Preoperative cognitive impairment assessed by the Minimum Mental State Examination (MMSE) (score =30 kg/m^2; 4. Severe carotid artery stenosis (stenosis rate >=70%) or a history of carotid endarterectomy/stenting; 5. Acute cerebrovascular events (cerebral infarction, intracerebral hemorrhage, transient ischemic attack [TIA]) within the past 3 months; 6. Severe hepatic or renal insufficiency, severe cardiopulmonary dysfunction; 7. Inability to complete cognitive assessment due to severe visual or hearing impairment or language barriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium (POD) defined by positive 3D-CAM assessment at any time point within 7 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to extubation;Length of stay in PACU;Unplanned admission to ICU;Postoperative hospital length of stay;Postoperative complications (e.g., stroke, heart failure, pulmonary infection);Visual Analog Scale (VAS) pain score;Richmond Agitation-Sedation Scale (RASS) score;C-reactive protein (CRP);Albumin;Hemoglobin (Hb);Blood glucose;Electrolytes;Liver and renal function; | — |
Countries
China
Contacts
Public ContactLiu Yatao
The First Hospital of Lanzhou University
Outcome results
None listed