Sepsis
Conditions
Interventions
Sepsis group:None
Healthy control group:None
Non-septic infection group:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Group A criteria (200 patients) : patients were enrolled in the observational study if they met all of the following criteria: (1) age >=18 years old; (2) Initial screening (qSOFA >= 2 or high clinical suspicion of infection) in emergency department, hematology department and ICU; (3) Patients or their family members were able to understand the study protocol and willing to participate in the study, and provided written informed consent. Group B criteria (150 patients) : patients were enrolled in the observational study if they met all of the following criteria: (1) age >=18 years old; (2) Patients were diagnosed with infection in the emergency department, hematology department, and ICU without organ dysfunction (SOFA=18 years old; (2) good health without signs of infection;
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients could not be selected for clinical study if they had any of the following conditions: (1) Age: < 18 years old; (2) pregnant or lactating women; (3) severe immunosuppression: such as HIV/AIDS, long-term use of immunosuppressive agents, organ transplantation; (4) received blood transfusion or blood products within 1 year; (5) diagnosed hematological diseases, such as leukemia and lymphoma; (6) The samples did not meet the requirements, such as hemolysis, coagulation, blood collection time overtime, etc. (7) Inability to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: Diagnosis of sepsis according to Sepsis-3 criteria;Area Under the Receiver Operating Characteristic Curve (AUC) of the Multi-parameter Diagnostic Model;Laboratory test indicators:1. nCD64 Index; 2. Monocyte Distribution Width (MDW); 3. Neutrophil Stiffness (Deformability); 4. Cell Aspect Ratio; 5. Cell Subset Size Distribution; | — |
Countries
China
Contacts
Public ContactYin Lu
Peking University Shenzhen Hospital
Outcome results
None listed