Painless Gastroscopy
Conditions
Interventions
Low-dose Alfentanil Group:A low dose of 5 µg/kg alfentanil was administered intravenously,followed by an initial dose of 0.15 mg/kg remimazolam administered intravenously.
Medium-dose Alfentanil Group:A medium dose of 10 µg/kg alfentanil was administered intravenously,followed by an initial dose of 0.10 mg/kg remimazolam administered intravenously.
Sponsors
The First Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old;? 2. Body Mass Index (BMI) between 30 and 39.9 Kg/m²;? 3. American Society of Anesthesiologists (ASA) physical status classification of Class I, II, and stable Class III
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to the drugs used; 2. History of alcohol abuse; 3. Use of opioids or benzodiazepines within 6 months; 4. Refusal of anesthesia; 5. Uncontrolled severe hypertension (SBP >= 180 mmHg, DBP >= 110 mmHg); 6. Recent respiratory tract infection, history of asthma, chronic obstructive pulmonary disease (COPD) or other respiratory diseases; 7. History of liver dysfunction (Child-Pugh Class B or above) or renal dysfunction; 8. History of cardiovascular diseases; patients with pyloric obstruction, achalasia, or a history of upper gastrointestinal surgery; 9. Patients with mental illness or inability to communicate effectively; 10. Patients undergoing complex or therapeutic gastroscopy; 11. Expected difficult airway (Mallampati classification >= Grade 3); 12. Patients suspected of having obstructive sleep apnea-hypopnea syndrome (OSAHS history).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure (SBP);Hypotension; Hypoxemia; Bradycardia; Singultus; Injection pain; Nausea and vomiting;Diastolic Blood Pressure (DBP);Mean Arterial Pressure (MAP);Pulse Oxygen Saturation (SpO?);Heart Rate (HR); | — |
Countries
China
Contacts
Public ContactXiao Song
Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Shandong First Medical University
Outcome results
None listed