Colorectal Cancer
Conditions
Interventions
Case Group(Cholecystectomy History Group (CCE)):None
Control Group(No Cholecystectomy History Group (CCE)):None
Sponsors
The First Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age of 18-75 years old, male or female. (2) Colorectal adenocarcinoma was initially diagnosed by preoperative colonoscopy biopsy pathology, and radical surgery (R0 resection) was planned. (3) Case group (CCE?) : patients with a history of cholecystectomy (benign colorectal cancer confirmed by postoperative pathology), and the resection time was at least 1 year before the diagnosis of colorectal cancer. (4) Control group (CCE? group) : no history of cholecystectomy. (5) They voluntarily participated in and signed the specific informed consent for the use of their surgical specimens and related data for this study.
Exclusion criteria
Exclusion criteria: (1) patients received any neoadjuvant therapy (including radiotherapy, chemotherapy, targeted therapy, or immunotherapy) before surgery. (2) use of antibiotics or probiotics within 1 month before surgery; (3) complicated with active intestinal infection, inflammatory bowel disease, complete intestinal obstruction or intestinal perforation. (4) complicated with other active malignant tumors, autoimmune diseases or requiring long-term use of immunosuppressants. (5) emergency surgery patients;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative abundance of 7a-dehydroxylating bacteria in tumor tissue;Tumor tissue deoxycholic acid (DCA) concentration;Infiltration density of Foxp3? regulatory T cells (Tregs) in tumor stroma; | — |
Secondary
| Measure | Time frame |
|---|---|
| DCA concentration in adjacent normal tissue;Relative abundance of 7a-dehydroxylating bacteria in adjacent normal tissue;Tumor clinicopathological features(TNM stage, differentiation grade, tumor location);Infiltration density of Foxp3? Tregs in adjacent normal tissue stroma;Preoperative serum secondary bile acid profile;Preoperative proportion of Tregs in peripheral blood;Preoperative fecal microbiota composition; | — |
Countries
China
Contacts
Public ContactYu Yaqun; Lin Kangqiang
The First Affiliated Hospital of Guilin Medical University
Outcome results
None listed