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Research on the evolution of healthcare-associated multi-drug resistant organism based on bacteriophages and the mechanism and application of bacteriophage cocktail intervention in infection transmission

Research on the evolution of healthcare-associated multi-drug resistant organism based on bacteriophages and the mechanism and application of bacteriophage cocktail intervention in infection transmission

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122920
Enrollment
Unknown
Registered
2026-04-20
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Experimental group:Routine disinfection+bacteriophage spray
Control group:Using conventional disinfection methods such as chlorine containing disinfectants

Sponsors

Zhongshan hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Environmental contamination by drug-resistant bacteria; 2. Spray can be used as an environmental disinfection measure; 3. The surface of environmental objects can be sampled.

Exclusion criteria

Exclusion criteria: 1. No antibiotic resistant bacteria contamination in the environment; 2. The environment is not suitable for using spray as disinfection measure; 3. Surface of environmental objects cannot be sampled; 4. Other situations that may lead to inconsistent implementation of intervention measures and interruption of data collection.

Design outcomes

Primary

MeasureTime frame
Clearance rate of multidrug-resistant bacteria in ICU bed unit environment 24 hours after intervention;

Secondary

MeasureTime frame
The effectiveness of constructing a phage library of multidrug-resistant bacteria in ICU;Long term effect of bacteriophage cocktail in eliminating multidrug-resistant bacteria;The clearance effect of bacteriophage cocktail combined with different disinfectants on multidrug-resistant bacteria and their biofilms;

Countries

China

Contacts

Public ContactJiabing Lin

Zhongshan hospital, Fudan University

lin.jiabing@zs-hospital.sh.cn+86 158 0083 9313

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026