Analgesic effect after lower limb orthopedic surgery in children
Conditions
Interventions
Bupivacaine hydrochloride group:After anesthesia induction, peripheral nerve block was performed under ultrasound guidance with 0.25% bupivacaine. A single dose of 5mg/kg was administered, and the tot
Bupivacaine liposome group:After anesthesia induction, peripheral nerve block was performed under ultrasound guidance with 0.665% liposomal bupivacaine liposomes. A single dose of 3mg/kg was administe
Sponsors
Hunan Children’ Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. 6 years old <=age age <=17 years old 2. ASAI or Grade II 3. BMI: 18 kg/m^2 <BMI <30 kg/m^2 4. Selective orthopedic surgery for lower limbs 5. Plan to undergo nerve block 6. Postoperative planning to use PCIA for analgesics 7. Parents or guardians sign informed consent form and are able to follow the research plan
Exclusion criteria
Exclusion criteria: 1. There are previous neurological diseases that affect pain perception or anesthesia, such as epilepsy, spinal cord injury, peripheral nerve injury, etc 2. Contraindications of general anesthesia or nerve block 3. Use opioids within 1 month before the operation; long-term opioid use history (more than 1 month) 4. Patients with mental or cognitive impairment who cannot follow the study protocol 5. Patients who are allergic to bupivacaine liposomes or bupivacaine hydrochloride or contraindications 6. History of chronic pain 7. There are serious comorbidities in preoperative evaluation 8. Other diseases that may interfere with the study results 9. Those who were transferred to ICU treatment after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS-AUC Pain Score within 72 hours after anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphine consumption equivalent within 72 hours after surgery;Comprehensive pain index and opioid consumption score within 72 hours of postoperative surgery;The incidence of moderate to severe pain within 72 hours after surgery;Adverse Event Rate; | — |
Countries
China
Contacts
Public ContactWei Siwei
Hunan Children’ Hospital
Outcome results
None listed