Non-small cell lung cancer (NSCLC) with bone metastases
Conditions
Interventions
Immune/Targeted Therapy Observation Group:None
Sponsors
The Army Specialty Medical Center of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with histologically or cytologically confirmed non-small cell lung cancer (NSCLC, including adenocarcinoma, squamous cell carcinoma, and other NSCLC subtypes), aged = 18 years, regardless of gender, with an expected survival = 3 months; 2.Patients with suspected bone metastases diagnosed by CT, PET-CT, MRI, or bone scan prior to enrollment; 3.Received first-line immunotherapy or targeted therapy for NSCLC, with regimens consistent with the recommendations of the Chinese Society of Clinical Oncology (CSCO) Guidelines for the Diagnosis and Treatment of Non-Small Cell Lung Cancer; 4.Presence of at least one measurable non-bone lesion; 5.Voluntarily signed informed consent, with good communication skills and compliance, able to cooperate with scheduled follow-up visits and relevant examinations as required by the study
Exclusion criteria
Exclusion criteria: 1.Concurrent malignanc; 2.Severe dysfunction of vital organs including heart, liver and kidney, or active infection, unable to tolerate protocol-specified treatment and follow-up; 3.Previous exposure to immunotherapy or targeted therapy, or receipt of local radiotherapy for bone metastases prior to study treatment; 4.Uncertain diagnosis of bone metastases; 5.Presence of psychiatric disorders, cognitive impairment or communication barriers, unable to cooperate with follow-up and data collection; 6.Female patients who are pregnant or lactating;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival (PFS);Efficacy;Bone Efficacy;Bone Progression-Free Survival (Bone PFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival (OS); | — |
Countries
China
Contacts
Public ContactYang,xueqin
The Army Specialty Medical Center of the People's Liberation Army of China
Outcome results
None listed