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The effect of ultrasound-guided thoracic paravertebral nerve block with different concentrations of methylene blue combined with ropivacaine on postoperative rebound pain after thoracoscopic lobectomy

The effect of ultrasound-guided thoracic paravertebral nerve block with different concentrations of methylene blue combined with ropivacaine on postoperative rebound pain after thoracoscopic lobectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122907
Enrollment
Unknown
Registered
2026-04-20
Start date
2026-04-28
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rebound pain after nerve blockage

Interventions

Control group (D) group:0.35% ropivacaine 20ml was administered for ultrasound-guided thoracic paravertebral nerve block
Methylene Blue Group 1(Y1) group:20 ml of 0.35% ropivacaine and 0.01% methylene blue were used for ultrasound-guided thoracic paravertebral nerve block.
Methylene Blue Group 2(Y2) group:20 ml of 0.35% ropivacaine and 0.025% methylene blue were used for ultrasound-guided thoracic paravertebral nerve block.

Sponsors

Neijiang First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Age: 18 - 70 years old; 2.ASA classification grades I - III; 3.Patients who need to undergo thoracoscopic surgery; 4.Voluntarily participate in this research.

Exclusion criteria

Exclusion criteria: 1.Patients who are unable to clearly describe their pain; 2.Patients who have recently used sedatives or anesthetic drugs; 3.There are patients with severe functional impairments of organs such as the heart, liver and kidneys; 4.Other cases that are not suitable for participation in this study; 5.Any disease that makes it difficult for the patient to cooperate; 6.Those who are allergic to the relevant anesthetic drugs; 7.Those with contraindications to paravertebral puncture; 8.Patients with G6PD deficiency.

Design outcomes

Primary

MeasureTime frame
The incidence of rebound pain after nerve block;

Secondary

MeasureTime frame
The highest NRS score when rebound pain occurs;Postoperative resting and active NRS scores;Coughing ability;

Countries

China

Contacts

Public ContactLi Siyan

Neijiang First People's Hospital

905373501@qq.com+86 183 8108 1160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026