Breast Cancer
Conditions
Interventions
Gold Standard:The histopathological diagnosis of breast lesion specimens obtained through ultrasound/MRI-guided biopsy or surgical resection serves as the gold standard for breast cancer diagnosis
for breast cancers diagnosed during the 1-year follow-up period, the final pathological diagnosis result is used as the reference standard.
Index test:Breast ultrasound combined with breast enhanced magnetic resonance imaging (BMRI) examination
Sponsors
Zigong First People's Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 35 - 65 years old; 2. No symptoms related to breast cancer; 3. Voluntary to sign the informed consent form and cooperate with 1-year follow-up; 4. No contraindications for MRI examination (no metal implants, no allergy to contrast agents, normal renal function).
Exclusion criteria
Exclusion criteria: 1. Previous history of breast cancer / breast carcinoma in situ or history of breast surgery; 2. Those with breast implantation; 3. Pregnant women / lactating women, women in the premenstrual period, those with severe liver or kidney dysfunction, those with coagulation disorders, and those who refuse pathological biopsy or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of breast ultrasound combined with enhanced MRI for breast cancer screening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of interval breast cancer during 1-year follow-up;Predictive performance of BCSC, Gail and PUMCH breast cancer risk prediction models;The incidence rate of adverse events related to breast enhanced MRI examinations; | — |
Countries
China
Contacts
Public ContactZhao Qian
Zigong First People's Hospital
Outcome results
None listed