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Effect of Nutrient Oral Nutritional Supplementation During Small Bowel Decompression on Postoperative Intestinal Barrier Function and Clinical Outcomes in Patients with Obstructive Colorectal Cancer: A Randomized Controlled Trial

Effect of Nutrient Oral Nutritional Supplementation During Small Bowel Decompression on Postoperative Intestinal Barrier Function and Clinical Outcomes in Patients with Obstructive Colorectal Cancer: A Randomized Controlled Trial

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122869
Enrollment
Unknown
Registered
2026-04-20
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Colorectal Cancer

Interventions

Experimental Group:Following placement of the intestinal decompression tube, patients in the intervention group received trophic oral nutritional supplementation (ONS) for a minimum of 5 days. The tro
Control Group:Patients in the control group were kept nil per os (NPO) and received total parenteral nutrition (TPN) at 25 kcal/kg/day. Standard supportive care was provided, including gastric acid su

Sponsors

The Second Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18 years or older. 2. Patients diagnosed with colorectal cancer accompanied by incomplete intestinal obstruction via abdominal X-ray and abdominal CT examination, who had undergone placement of a transnasal intestinal decompression tube; the tube tip was confirmed to have reached the terminal ileum by abdominal upright radiography, with no significant air-fluid levels observed in the proximal bowel, followed by elective radical resection. 3. Voluntarily participated in the study and provided written informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients requiring emergency surgery, including but not limited to acute complete intestinal obstruction, bowel perforation, severe peritonitis, or sepsis secondary to colon cancer with obstruction necessitating immediate surgical intervention. 2.Pregnant or lactating women. 3.Patients on long-term high-dose corticosteroid therapy.

Design outcomes

Primary

MeasureTime frame
Incidence of Infectious Complications;Intestinal Barrier Function;Postoperative Length of Hospital Stay;

Secondary

MeasureTime frame
Serum Intestinal Barrier Markers;

Countries

China

Contacts

Public ContactSun Dali

The Second Affiliated Hospital of Kunming Medical University

945341793@qq.com+86 135 7704 7806

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026