Intracerebral Hemorrhage
Conditions
Interventions
Experimental Group:Multimodal brain-machine interfaces combined with functional electrical stimulation
Control Group:Default mode functional electrical stimulation
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.First onset, diagnosed as hemorrhagic stroke, in accordance with the definition of stroke in the "Key Points for the Diagnosis of Major Cerebrovascular Diseases in China 2019". 2.Vital signs are stable, disease duration >=6 months; condition is stable, consciousness is clear; no communication barriers. 3.A Mini-mental State Examination (MMSE) score of >=20 indicates the ability to understand instructions and cooperate with BCI training. 4.Unilateral limb paralysis, with the affected upper limb at Brunnstrom stages II to V, and modified Ashworth scale (MAS) for elbow flexor muscles and wrist flexor muscles at grade = 25 points or a Kinaesthetic and Visual Imagery Questionnaire (KVIQ-20) score>= 55 points.
Exclusion criteria
Exclusion criteria: 1.Age 70 years; 2.End-stage malignant disease; post-stroke disuse syndrome; history of seizures; 3.Serious cognitive impairments and a Mini-Mental State Examination (MMSE) score of less than 20 points, with hearing impairments, visual impairments, aphasia, and other disabilities that cannot cooperate with training. 4.Unable to complete MRI examination (such as claustrophobia or implanted metal devices, etc.); 5.Suffering from neuromuscular diseases that affect the motor function of the upper limbs, such as limb fractures, peripheral neuropathy, muscle injuries, etc. 6.Patients with severe upper limb dysfunction, unable to measure the motor evoked potentials (MEP) of the affected cerebral area. 7.Clear history of other cognitive disorders, such as Alzheimer's disease, Parkinson's disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG;ARAT;Brain fNIRS imaging;FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved Ashworth Rating Scale;SDS;Mini-mental State Examination, MMSE;PRPS;Modified Barthel Index Scores (MBI);Brunnstrom classification;fMRI;Montreal Cognitive Assessment, MoCA;HGRT;KVIQ;SAS; | — |
Countries
China
Contacts
Public ContactZhouping Tang
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed