Postoperative Delirium
Conditions
Interventions
Esketamine Group:Administer 0.25 mg/kg of esketamine intravenously during the induction of anesthesia.
Control Group:Administer an equivalent volume of normal saline intravenously during the induction of anesthesia.
Sponsors
Fujian Medical University Affiliated Longyan First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years 2.American Society of Anesthesiologists (ASA) physical status classification I-III 3.Mini-Mental State Examination (MMSE) score >= 24. 4.Scheduled for elective spinal surgery under general anesthesia
Exclusion criteria
Exclusion criteria: 1.Refusal to provide written informed consent 2.History of delirium, severe cognitive impairment, or recent use of psychoactive medications (affecting the central nervous system) 3.Severe cardiovascular or cerebrovascular disease 4.Severe hepatic or renal dysfunction 5.Severe respiratory disease 6.History of glaucoma 7.Inadequately treated or untreated hyperthyroidism 8.Known allergy or hypersensitivity to esketamine 9.Severe visual or hearing impairment, or any other condition precluding effective communication with the assessor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain;Postoperative fatigue severity;Sleep disturbance;Intraoperative consumption of sufentanil and remifentanil;Quality of post-operative recovery;Postoperative adverse reactions (nausea/vomiting, headache/dizziness, agitation);Changes in blood biomarkers potentially associated with delirium;Record operative duration, time to extubation after surgery, and length of stay in the post-anesthesia care unit (PACU); | — |
Countries
China
Contacts
Public ContactLi Shihai
Fujian Medical University Affiliated Longyan First Hospital
Outcome results
None listed