Severe Neurological Patients with Aspiration Pneumonia
Conditions
Interventions
Control Group:Patients were subjected to conventional neurocritical care, including anti-infection therapy, correction of fluid-electrolyte and acid-base imbalances, dehydration and intracranial press
Experiment group:In addition to the control group’s treatment, patients received Sivelestat sodium therapy.
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for neurocritical illness: patients with underlying conditions such as stroke or traumatic brain injury, who developed life-threatening conditions including impaired consciousness, quadriplegia, respiratory muscle paralysis, or respiratory failure after disease onset were classified as neurocritical cases; 2. Meeting the diagnostic criteria for aspiration pneumonia: presence of risk factors such as impaired consciousness, dysphagia, or poor oral hygiene, combined with clinical evidence of aspiration (e.g., sudden dyspnea, irritative cough) and imaging findings showing gravity-dependent pulmonary infiltrates; 3. Signed informed consent obtained from the patient's family or legal representative; 4. Complete clinical data without missing information.
Exclusion criteria
Exclusion criteria: 1. History of previous allergy to the study drug; 2. Pregnant or lactating women; 3. Refusal of family members to cooperate; 4. Coexisting chronic obstructive pulmonary disease (COPD), interstitial lung disease, or other pulmonary diseases; 5. Presence of confirmed extrapulmonary infection leading to pulmonary infection; 6. Patients with hematological or immune system disorders; 7. Patients with hepatic or renal insufficiency; 8. Patients with active bleeding or coagulation dysfunction; 9. Patients with malignant tumors; 10. Long-term use of systemic immunosuppressants or chemotherapeutic agents; 11. History of arrhythmia; 12. History of aspiration pneumonia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| partial pressure of oxygen; | — |
Secondary
| Measure | Time frame |
|---|---|
| partial pressure of carbon dioxide;heart rate;mean arterial pressure;Interleukin-6;C-reactive protein;Procalcitonin;acute physiology and chronic health evaluation;clinical pulmonary infection score;the durations of mechanical ventilation;length of ICU stay;incidence of adverse reactions;28-day mortality rate; | — |
Countries
China
Contacts
Public ContactWang Lei
The Second Affiliated Hospital of Shandong First Medical University
Outcome results
None listed