Primary biliary cholangitis
Conditions
Interventions
The IgG elevated PBC group and the IgG normal PBC group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years; 2. Meet the diagnostic criteria for primary biliary cholangitis; 3. Alanine aminotransferase and aspartate aminotransferase levels below 5 times the upper limit of normal; 4. Received standard-dose ursodeoxycholic acid therapy for at least 1 year, with or without concomitant immunosuppressive therapy; 5. Follow-up duration at the study center of at least 1 year.
Exclusion criteria
Exclusion criteria: 1. Coexisting other autoimmune liver diseases, including primary sclerosing cholangitis, autoimmune hepatitis, or any type of overlap syndrome; 2. Coexisting viral hepatitis, alcoholic liver disease, fatty liver disease, drug-induced liver injury, or hereditary liver disease; 3. Missing key baseline or follow-up data; 4. Ursodeoxycholic acid therapy duration of less than 1 year or suboptimal dosage; 5. Follow-up duration of less than 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical remission;Death;Liver transplantation;Relapse; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to obtain complete remission; | — |
Countries
China
Contacts
Public ContactYang Li
West China Hospital, Sichuan University
Outcome results
None listed