Infertility
Conditions
Interventions
Chinese Medicine Group:Bushen Antai Decoction Granules (Astragalus membranaceus 30g, Angelica sinensis 20g, Ligusticum chuanxiong 10g, Cuscuta chinensis 20g, Taxillus chinensis 15g, Dipsacus asper 15g
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: 1. Met the Rotterdam diagnostic criteria for PCOS; 2. Patients who have undergone at least two consecutive transfer cycles (fresh or thawed transfer cycles) and have not achieved clinical pregnancy after transferring two high-quality blastocysts or four high-quality cleavage-stage embryos, and are planning to undergo another thawed transfer (with available high-quality blastocysts in storage); 3. Age < 40 years; 4. Patients agreed to receive the treatment of this group and signed informed consent forms.1) Meeting the Rotterdam PCOS diagnostic criteria;
Exclusion criteria
Exclusion criteria: 1. PGT cycle; recurrent miscarriage; genital tract malformations; intrauterine adhesions; thin endometrium (<7mm); submucosal uterine fibroids or intramural fibroids affecting cavity morphology; moderate-to-severe endometriosis; autoimmune diseases; chromosomal abnormalities in either partner. 2. Hydrosalpinx without prior ligation or salpingectomy. 3. Received TCM therapies (e.g., acupuncture) within the past 3 months. 4. Patients undergoing testicular sperm extraction (TESE) or micro-TESE. 5. Severe primary diseases of the heart, liver, lungs, kidneys, brain, or hematologic system; or psychiatric disorders. 6. Endocrine disorders caused by other primary diseases, such as adrenal hyperplasia, hyperprolactinemia, thyroid diseases, or tumors. 7. Severe adverse reactions to study drugs. 8. Unwillingness to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrial Thickness (on the day of endometrial transformation);Embryo implantation rate;Persistent pregnancy rate;Live birth rate;Early miscarriage rate;Late miscarriage rate;Uterine endometrial hemodynamic parameters (RI, PI, S/D); | — |
Countries
China
Contacts
Public ContactXu Bei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed