Suspension laryngoscopy surgery
Conditions
Interventions
Experimental group:At time T0, administer 0.15 mg/kg of mivacurium. Administer sedation at 60 seconds after T0. Insert the tube at 240 seconds after T0.
Control group:At T0, administer 0.2 mg/kg mivacurium chloride. At T0 + 60 seconds, insert the tube.
Sponsors
The General Hospital of the Northern Theater Command of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old. 2. ASA classification: Grade I or II. 3. Scheduled for laryngeal surgery under general anesthesia with a laryngeal support device. 4. Body Mass Index (BMI): 18.5 - 28.0 kg/m^2. 5. Voluntary participation and signing of a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Predicted as a difficult airway (Mallampati grade = III, mouth opening < 3 cm, mentohyoid distance < 6 cm, or with a clear history of difficult airway). 2. Known to be allergic to propofol, remifentanil, and mivacurium. 3. Severe liver and kidney dysfunction. 4. Suffering from neuromuscular disorders. 5. Pregnant or lactating women. 6. Long-term use of drugs that affect neuromuscular conduction. 7. Other conditions judged by the researcher as not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Cooper score for tracheal intubation conditions (score range: 4–12); | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset time;Clinical duration;Recovery index;Time from drug discontinuation to TOF >= 0.9;TOF ratio at extubation;PACU length of stay;Area under the curve (AUC) for MAP below 20% of baseline;Incidence of intraoperative body movements requiring intervention;Proportion of patients who did not receive neuromuscular blocking reversal agents;Incidence of required assisted ventilation during the induction period (experimental group);Incidence of sore throat;Incidence of PONV;Patient and surgeon satisfaction;QoR-15 at 24 hours postoperatively; | — |
Countries
China
Contacts
Public ContactDiao Yugang
The General Hospital of the Northern Theater Command of the People's Liberation Army of China
Outcome results
None listed