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Longitudinal Evolution of PET/MR Imaging Features From the Acute to Follow-up Phase in Patients with Brain Injury Complicated by Coma: An Observational cohort Study

Longitudinal Evolution of PET/MR Imaging Features From the Acute to Follow-up Phase in Patients with Brain Injury Complicated by Coma: An Observational cohort Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122810
Enrollment
Unknown
Registered
2026-04-17
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute disorders of consciousness

Interventions

Sponsors

Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with brain injury who were previously admitted to our institution and have completed two PET/MR examinations; 2. Diagnosed with traumatic brain injury or hemorrhagic stroke; 3. Age range: 18–80 years; 4. Glasgow Coma Scale (GCS) score of 3–8 on the day of onset; 5. The first PET/MR examination was performed 10–28 days post-onset; 6. The second PET/MR examination was performed approximately 3 months post-onset; 7. Follow-up of more than six months was completed;

Exclusion criteria

Exclusion criteria: 1. Death occurred during the follow-up period; 2. Declined to participate in the study; 3. History of malignant neoplasm; 4. History of prior neuropsychiatric disorders; 5. PET/MR imaging data was deemed non-qualified;

Design outcomes

Primary

MeasureTime frame
The state of consciousness at three months post-onset;The correlation between the evolution of imaging features and prognosis;

Secondary

MeasureTime frame
The state of consciousness at six months post-onset;

Countries

China

Contacts

Public ContactWang Xi

Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)

xiwang_199112@163.com+86 25 68303064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026